I saw the above video by Tom AK2B where he shows what he calls subway style of building. I wanted to try it so I bought a drill bit that is supposed to be used for wood and modified it a bit so that when making the 'islands' the drill bit will not go through the PCB. Below is an image of the latest project, an audio amplifier where I tried this. The image is taken in the middle of the build process so you can see some unused pads.
The result was very good and I will probably continue to use it. Here is a video with the audio amp is being tested:
BTW, the music is Motor City Drum Ensemble with Stuttgart Nights!